Laboratory services for molecular biology, microbiology, peptide and protein chemistry

CBI Services provides drug discovery and diagnostic development organizations a broad range of world-class laboratory services to bring new products to market.

Located in a 32,000 square foot laboratory in Richmond, Virginia, CBI Services is one of the world's most comprehensive Contract Research Organizations in operation. CBI Services provides reliable expertise and cutting-edge technologies which are not available from other companies.

An expert core laboratory, we provide consultation on experimental design and offer comprehensive services under GLP and non-GLP compliance. These services are offered individually or can be integrated to support product development from discovery-to-market with full Regulatory Support under FDA GLP Guidelines 21 CFR 58.

CBI Services provides the following capabilities to clients:

Molecular biology
We provide comprehensive services from gene target identification through custom molecular biology-based assay development, including:

• DNA sequencing & variant detection (SNP)
• Gene expression and analysis
• Gene synthesis, primer & probe design
• Custom molecular assays
• Bioinformatics analysis and annotation

Protein expression & analysis and peptide synthesis & purification
We provide services for the expression, production, isolation, analysis, characterization of proteins, peptides, and antibodies including:

• Peptide synthesis and mapping
• Recombinant protein expression (multiple systems)
• Antibody production
• Protein and antibody purification
• Scale-up fermentation
• Biochemical analysis & amino acid composition
• Biophysical characterization and ligand binding

Bio-analytical services (CLIA certified)

• Custom bio-analytic development
• Safety, efficacy and potency of biologics
• Primary endpoint determinations
• Specialized safety assays
• Biomarker and surrogate endpoint studies
• Immunogenic response
• Biologics characterization

Assay development and validation
CBI Services provides immunogen or epitope sequence information, through purification and characterization of a therapeutic or diagnostic antibodies, including:

• ELISA development
• Immunogen/epitope preparation and characterization
• Monoclonal antibodies
• Polyclonal antisera
• Monospecific polyclonal antisera
• Antibody characterization
• Labeled antibodies

Microbiology, virology & biosafety testing (BSL3 facilities)
Combining general microbiology with modern molecular-based methodologies, CBI Services offers a very unique complement of services for the isolation and identification of bacterial and viral agents, including:

• General microbiology
• Molecular-based detection
• BioSafety
• BSL-3 facility (CDC & USDA License)
• Biodefense; Detection of pathogens including select agents

Program expertise
Our experienced scientific teams have successfully managed end-to-end projects for multiple biopharmaceutical and diagnostic organizations and can work with your group on projects in the following areas:

• Discovery programs
• Preclinical programs
• Clinical programs
• Bio-analytical services (CLIA certified)
• Biological production & manufacturing
• Biomarker discovery programs