August 4, 2006                                                        Vol. 1, Issue 2


Welcome Back!

For those of you who have been checking your front porches on a daily basis for your copy of "CBI Messenger," I apologize for the delay. Hopefully it will be worth the wait and, of course, you will not be charged for this issue. Most of the delay resulted from putting in place and publicly announcing our exciting new relationship with PharmAust, Ltd, an Australia based life sciences services company and the potential acquisition of one of its subsidiaries, Mimotopes, Pty, Ltd.

Delays notwithstanding, this issue has a timely article on avian flu authored by Jim Joyce, President & CEO of Aethlon Medical. Aethlon has a device that could help in reducing viremia, including avian flu, in a variety of instances. CBI is working with Aethlon in the area of biothreat agents.

Also, Tom Reynolds contributes a technology focus article on the newest approach in the gene therapy area and a new service offering by the company, RNAi. This approach, while in its infancy, holds real promise for a successful gene therapy paradigm.

Finally, you'll find a Q&A piece with Dr. Joseph Chimera, our new Vice President, Sales, Marketing, and Business Development, whom we recruited to re-balance government and commercial revenues. He is re-packaging the company's offerings to focus client attention on our ability to support a process rather than the ability to provide a technology.

I hope you all enjoy the read. All suggestions to improve this newsletter are welcome.

Richard Freer
Chairman
[email protected]
August 3, 2006


Feature Story
 

   

 

Bird Flu Complacency

by James. A. Joyce
Chairman & CEO, Aethlon Medical, Inc 


Earlier this year, the media deployed the best and brightest from the science world to discuss the imminent threat of Bird Flu mutating into a form that would allow for human-to-human infection. ABC News produced a special
report on world-renowned researcher Dr. Robert G. Webster, who stated: "Society just can't accept the idea that 50 percent of the population could die, and I think we have to face that possibility." However, as time passed, the public became distracted by multiple wars in the Middle East, inflation, rising oil prices, tumbling financial markets, global warming, and a host of other issues. Unfortunately, evolving evidence underscores the reality that Bird Flu, otherwise know as H5N1 Avian Influenza, is still a very real threat.

Influenza is already a big killer, as it is responsible for more than 35,000 deaths and more than 200,000 hospitalizations in the United States each year. Avian flu occurs naturally in birds and has historically demonstrated the ability to infect humans. It already is unprecedented as an animal illness in its rapid expansion, and has cost 300 million farmers more than $15 billion during its recent spread in poultry around the globe. World Health Organization (WHO) officials claim the H5N1 strain of Avian Flu poses a greater challenge to the world than any other infectious disease, including AIDS. As of July 20th, WHO officials confirm that of the 230 individuals known to have been infected, 132 died since the virus re-emerged in 2003. More.

 

Research Notes
 

 

Flu Vaccine: Is the Cure Worse than the Disease?

by Tom Reynolds

Have you had your flu shot lately? If so, you probably had a good experience as did the vast majority of your fellow flu shot recipients. For five bucks you got immunity to the flu this year. The only likely side effect was a sore arm - and even that can be avoided thanks to the newly available FluMist nasal flu vaccine. But an unlucky few suffered side effects. Between 5 to 10 percent of all people immunized experience "adverse events" -- to use the terminology of the vaccine development world -- including mild to moderate flu-like symptoms.

But an unlucky few suffered side effects. Between 5 to 10 percent of all people immunized experience "adverse events" -- to use the terminology of the vaccine development world -- including mild to moderate flu-like symptoms.

 

If the cure causes the misery you were trying to avoid in the first place, some folks wonder, "What's the point getting vaccinated?" Well, according to the Centers for Disease Control, getting the shot drastically reduces the chance of getting serious complications from the flu. The vaccination is highly recommended for anyone over 65 or for anyone caring for an immuno-compromised person.


That sounds like sage advice but people still complain. It is only human nature to associate a cause and effect: Most people get the flu vaccine in the fall and winter when other viruses are circulating. If they get a fever or cold from infection with a different virus, they can't tell the difference, and understandably associate it with the vaccine. More.

 

Q&A with Joseph Chimera

    CBI recently hired Dr. Joe Chimera to bolster commercial contract revenues. As the new Senior Vice President for Sales, Marketing and Business Development he not only has the longest title in the company, he also has one of the most daunting charges in the company: restoring the revenue balance between the government and commercial sectors.

We tapped Joe for this position following a national search and interviews with several outstanding candidates. In the exhaustive search process, which went well  beyond the usual resume review and reference checks, we asked  each candidate to critique our program – where were we lacking, and how should we consider changing -- and make suggestions for new directions. Some candidates found the exercise intimidating but Joe responded with candor and insight based upon his extensive experience. Some of our questions and his responses follow:

Joe, what in your background best addresses our need to grow commercial revenue?

 

There are several points. First, as you know from my resume, I have extensive training in modern molecular biology, including an advanced degree and post-doctoral training. I know the technology. More

Commonwealth Biotechnologies, Inc., collaborates with clients to solve complex laboratory testing problems at its secure, state-of-the-art facilities in Richmond, Va.


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Investor Relations

Commonwealth Biotechnologies, Inc., Signs a Term Sheet with PharmAust, Ltd., to Acquire Mimotopes, Pty. Ltd. CBI announced today that it has signed a non-binding term sheet to acquire the outstanding capital stock of Mimotopes Pty., Ltd., a wholly owned subsidiary of PharmAust Ltd. July 26, 2006. More.

CBI announces Strategic Alliance Agreement with PharmAust, Ltd.
Commonwealth Biotechnologies, Inc., and 
PharmAust, Ltd., an Australia-based biotech services company have signed a Strategic Alliance and Client Referral Agreement to co-market their services to the life sciences industry. July 17, 2006. More .

CBI Appoints Dr. Joseph Chimera as new Senior Vice President, Sales Marketing, and Business Development.
On July 1, 2006, Dr. Chimera joined CBI with the specific charge of expanding the commercial client base. May 25, 2006.
More.

Aethlon Medical and CBI sign cooperative research agreement to expand uses of Aethlon's "HemopurifierTM" to Biothreat Agents.  Aethlon Medical, Inc., a pioneer in developing therapeutic devices for infectious disease, announced today that it has signed a cooperative research agreement with Commonwealth Biotechnologies, Inc. March 29, 2006.
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Commonwealth Biotechnologies, Inc.
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